3-Methylaminopiperidine dihydrochloride
3-Methylaminopiperidine dihydrochloride
CAS: 127294-77-3
Molecular Formula: C6H16Cl2N2
3-Methylaminopiperidine dihydrochloride - Names and Identifiers
3-Methylaminopiperidine dihydrochloride - Physico-chemical Properties
| Molecular Formula | C6H16Cl2N2 |
| Molar Mass | 187.11 |
| Melting Point | 199-200°C |
| Boling Point | 253.7°C at 760 mmHg |
| Flash Point | 107.2°C |
| Water Solubility | Soluble in water |
| Vapor Presure | 0.0143mmHg at 25°C |
| Appearance | Crystalline powder |
| Color | White to Almost white |
| Storage Condition | Sealed in dry,Room Temperature |
| MDL | MFCD00673143 |
| Physical and Chemical Properties | Melting Point: 199-200°C |
3-Methylaminopiperidine dihydrochloride - Risk and Safety
| Risk Codes | 36/38 - Irritating to eyes and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| HS Code | 29333990 |
3-Methylaminopiperidine dihydrochloride - Reference Information
| Overview | 3-methylamine piperidine (1) is an important intermediate for the synthesis of fluoroquinolone antibacterial drug balofloxacin (balofloxacin). The literature uses γ-butyrolactone as raw material, 3-methylamine piperidine was obtained by amination, hydrolysis, esterification, condensation with ethyl bromoacetate, cyclization, ester hydrolysis and decarboxylation, reductive amination and hydrogen release of benzyl, etc., with long steps and low total yield (only 11.5%). 3-methylaminopyridine (4) was prepared by formylation and reduction of lithium aluminum hydride with 3-aminopyridine (2); or 2 was condensed with triethyl orthoformate and reduced with sodium borohydride to obtain 4,4 and then Pd/C reduction to obtain 3-methylaminopyridine diacetate with total yields of 16% and 32%, respectively. |
Last Update：2024-04-09 15:16:47
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